Liver Transplantation

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Pinching of the portal vein wall with the cannula in situ or pushing the tube into the right anterior or posterior PV is efficient for uniform flushing of the liver graft. The need for hepatic artery flushing by preservation flushing is controversial. Finally, in case of modified right lobe graft, vascular conduits using recipient's great saphenous vein, PV, umbilical vein, or cryopreserved cadaveric vessels are employed to establish the good outflow of the graft.

After introduction of cyclosporine, a number of new immunosuppressants tacrolimus, mycophenolate mofetil, sirolimus, interleukin-2 receptor blocker, humanized monoclonal antibody, etc are available currently. Vast majority of patients can be treated satisfactorily with boluses of steroids. In the majority of liver transplant recipients, combination of two or three different maintenance immunosuppressive drugs is used for prevention of rejection. The calcineurin inhibitors tacrolimus and cyclosporine are the mainstays of immunosuppression in liver transplantation.

Steroids are still almost universally used after liver transplantation. Most patients are discharged with steroids, which are subsequently tapered and weaned in the following months. Mycophenolate mofetil MMF , which is antimetabolites such as azathioprine, is also frequently used to reduce calcineurin inhibitor dose and to prevent or limit side effects such as renal dysfunction, hypertension and hyperlipidemia. Sirolimus Rapamycin is a new immunosuppressive agent, which is structurally similar to tacrolimus, and has antifibrotic and antineoplastic characteristics, but lack of nephrotoxicity.

However, severe side effects, including delayed wound healing and vascular complications limit its clinical usage. In the mean time, the present availability of a wide spectrum of effective and specific immunosuppressive drugs allows individualized selection of drugs, thereby limiting serious side effects. Postoperative technical and organic medical complications, primary dysfunction, graft rejection and infections are the major short-term complications Table 5. During the initial postoperative hours, abnormal liver biochemistries are typical and reflect a number of insults to the graft, including following harvesting, preservation, and subsequent reperfusion.

However, daily routine Doppler ultrasound exam should be performed to exclude vascular complications such as hepatic artery thrombosis, portal and hepatic vein stenosis or obstruction. Within the first week after LT, liver biochemistry steadily improve as ischemia and reperfusion damage resolves, and also the volume of transplanted liver graft is regenerating.

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Acute rejection becomes an important and frequent cause of graft dysfunction at 1 week and beyond. Liver biopsy is necessary for confirmatory diagnosis. Various infectious complications following liver transplantation can occur, and opportunistic infections related to intensive immunosuppresion are relatively common such as cytomegalovirus, Pneumocystis carinii, and fungal infection. Neurologic dysfunction, hyperglycemia and renal impairment can occur mainly related to the toxic effects of cyclosporine and tacrolimus.

Today, with improved survival in most transplant centers, increasing attention is being given to complications that develop in the long-term, and that are highly related to the immunosuppressive treatment. The most frequent complications are chronic renal failure, hypertension, diabetes mellitus, dyslipidemia, obesity, bone or neurological complications, development of de novo tumors. Impaired renal dysfunction before transplantation, chronic use of calcineurin inhibitors and hypertension probably all contribute to the increased risk for chronic renal failure after liver transplantation.

This combined with high risk behavior leads to a markedly increased risk for arthrosclerosis and subsequent cardiovascular events. Increased risk for osteoporosis in liver transplant recipient results from the combination of low bone mineral density before transplantation due to hepatic osteodystrophy, malnutrition and inactivity and steroid use after transplantation.

Varying degree of neurological complications develop in large proportion of liver transplant recipient mostly secondary to calcineurin inhibitor. Tremor is the most common symptom, and headache, paresthesia, or insomnia is other complaints that can be actually very disabling. Reduction of immunosuppressive drug dose might be helpful. Consequently, post-transplant management should focus on the elimination of risk factors, as well as minimizing the amount of immunosuppression.

Living-Donor Liver Transplant – Awareness :15 - UPMC

Currently, effective antiviral prophylaxis with high dose hepatitis B immunoglobulin has virtually eliminated HBV recurrence. Recurrence of hepatitis C is almost universally seen. It usually presents gradually in the postoperative courses, but accelerated compared to the pretransplant setting. Recurrence of HCC is especially common in patients with a poorly differentiated tumor or macroscopic vascular invasion. The outcome is universally dismal, but long-term survival is possible in a few selected cases received radical treatment.

Recurrence of autoimmune disease in an organ from a donor is immunologically intriguing. Diagnosis can be difficult due to other potential causes for graft dysfunction. Recurrence of an early stage of primary biliary cirrhosis may occur in a majority of patients transplanted for this indication in the long term, but seldom leads to cirrhosis. Retransplantation for recurrent disease is a difficult ethical issue faced by transplant teams in an era of intractable organ shortage.

Perioperative risk, survival, quality of life, as well as the presence of comorbidities such as renal failure related to immunosuppression toxicity all need to be weighed in the decision to retransplant. Liver transplantation has revolutionized the management of acute and chronic liver diseases.

The scarcity of donor organ is still the factors limiting its use. Expansion of the donor pool with increasing use of extended criteria organs has increased greatly over the last few decades. With improved survival in most transplant centers, increased attention should be given to complications that develop in the long-term. National Center for Biotechnology Information , U. Journal List Gut Liver v. Gut Liver. Published online Sep Find articles by Deok-Bog Moon. Find articles by Sung-Gyu Lee. Author information Article notes Copyright and License information Disclaimer.

Corresponding author. Correspondence to: Sung-Gyu Lee. Received Feb 20; Accepted Mar This article has been cited by other articles in PMC. Abstract Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. Keywords: Liver transplantation, Deceased donor liver transplantation, Living donor liver transplantation. Open in a separate window.

LDLT, living donor liver transplantation. Table 1 Contraindications to Liver Transplantation. Deceased donor whole liver transplantation 45 The recipient operation consists of total hepatectomy of the native liver followed by implantation of the donor liver. Living donor liver transplantation The surgical technique for recipients is based on whole liver resection, with preservation of the IVC removed for whole DDLT. Donor selection 1 Deceased liver donor Selection of an appropriate donor is crucial to the successful outcome of DDLT.

Donor procurement 1 Deceased liver donor Whole organ procurement is now a well described procedure. Types of graft in 1, adult-to-adult LDLTs. Early post-transplant complications Postoperative technical and organic medical complications, primary dysfunction, graft rejection and infections are the major short-term complications Table 5. Long-term complications Today, with improved survival in most transplant centers, increasing attention is being given to complications that develop in the long-term, and that are highly related to the immunosuppressive treatment.

References 1. Ahmed A, Keeffe EB. Current indications and contraindications for liver transplantation. Clin Liver Dis. Long-term survival after liver transplantation in consecutive patients at a single center. Ann Surg. Liver transplantation at the University of Pittsburgh, to Clin Transpl.

Ten years of liver transplantation: an evolving understanding of late graft loss. An analysis of late deaths after liver transplantation. Liver transplantation. Hepatology: a textbook of liver disease. Philadelphia: Saunders; Kim ST. Korean J Gastroenterol. Living-related donor liver transplantation: the Seoul experience. Transplant Proc. Toward liver transplants a year. Surg Today. Adult-to-adult living donor liver transplantation. J Korean Surg Soc.

Adult-to-adult living donor liver transplantation using extended right lobe grafts. Anterior segment congestion of right liver lobe graft in living donor liver transplantation and its strategy to prevent congestion. J Korean Soc Transplant. Modified right liver graft from a living donor to prevent congestion. An adult-to-adult living donor liver transplant using dual left lobe grafts. Lessons learned from living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl. Clinical transplants Lee SG. Current situation of liver transplantation.

Hepato-biliary-pancreatic surgery. Seoul: Eui-Hak Publishing; Outcome of liver transplantation for hepatitis B in the United States. Prevention of hepatitis B recurrence after living donor liver transplantation: primary high-dose hepatitis B immunoglobulin monotherapy and rescue antiviral therapy. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. Liver transplantation: an update. Neth J Med. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival.

Expanded indication criteria of living donor liver transplantation for hepatocellualr carcinoma at one large-volume center. Liver transplantation for hepatocellular carcinoma. Freeman RB. Estimating future hepatitis C morbidity, mortality, and costs in the United States. Am J Public Health. Curry MP. Hepatitis B and hepatitis C viruses in liver transplantation. Recurrence of diseases following orthotopic liver transplantation.

Am J Gastroenterol. Liver transplantation and hepatitis C virus: systematic review of antiviral therapy. Liver transplantation for alcoholic liver disease: current concepts and length of sobriety. Alcohol consumption patterns and predictors of use following liver transplantation for alcoholic liver disease. Lee WM. Acute liver failure. Early indicators of prognosis in fulminant hepatic failure. Which types of graft to use in patients with acute liver failure?

B I prefer living donor liver transplantation. J Hepatol. Application of intraoperative cine-portogram to detect spontaneous portosystemic collaterals missed by intraoperative Doppler exam in adult living donor liver transplantation. Living-donor liver transplantation with renoportal anastomosis for patients with large spontaneous splenorenal shunts. Technical modification of reno-portal anastomosis in living donor liver transplantation for patients with obliterated portal vein and large spontaneous splenorenal shunts.

Lopez PM, Martin P. Update on liver transplantation: indications, organ allocation, and long-term care. Mt Sinai J Med. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of patients. Koffron A, Stein JA. Liver transplantation: indications, pretransplant evaluation, surgery, and posttransplant complications. Med Clin North Am.

Living donor liver transplantation for acute-on-chronic liver failure: is it justified? Orthotopic liver transplantation with preservation of the inferior vena cava. Sugawara Y, Makuuchi M. Living donor liver transplantation: present status and recent advances. Br Med Bull. Techniques of reconstruction of hepatic veins in living-donor liver transplantation, especially for right hepatic vein and major short hepatic veins of right-lobe graft.

J Hepatobiliary Pancreat Surg. The introduction of microvascular surgery to hepatic artery reconstruction in living-donor liver transplantation: its surgical advantages compared with conventional procedures. Duct-to-duct biliary reconstruction in adult living donor liver transplantation.

Organ donors with primary central venous system tumor. Transplant tumor registry: donors with central nervous system tumors.

Busuttil RW, Tanaka K. The utility of marginal donors in liver transplantation. Lionaz C, Gonzalez EM. Marginal donors in liver transplantation. Fondevila C, Ghobrial RM. Donor selection and management. Transplantation of the liver. Philadelphia: Elsevier Saunders; Combination of extended donor criteria and changes in the Model for End-stage Liver Disease score predict patient survival and primary dysfunction in liver transplantation: a retrospective analysis.

Extended-donor criteria liver allografts. Semin Liver Dis. Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers. Am J Transplant. Said A, Lucey MR. Liver transplantation: an update Curr Opin Gastroenterol. Optimal utilization of donor grafts with extended criteria: a single-center experience in over liver transplants. Florman S, Miller CM. Live donor liver transplantation. A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines.

Current trends in live liver donation. Transpl Int. Hot topics in liver transplantation: organ allocation-extended criteria donor-living donor liver transplantation. Ethical guidelines for the evaluation of living organ donors. Can J Surg. Consensus statement on the live organ donor.

Living-donor liver transplantation in the United States: identifying donors at risk for perioperative complications. Fan ST. Live donor liver transplantation in adults. The effect of donor weight reduction on hepatic steatosis for living donor liver transplantation.

Successful ABO-incompatible pediatric liver transplantation utilizing standard immunosuppression with selective postoperative plasmapheresis. New protocol of immunosuppression for liver transplantation across ABO barrier: the use of Rituximab, hepatic arterial infusion, and preservation of spleen. Testa G, Benedetti E. Adult living-donor liver transplantation with ABO-incompatible grafts.

ABO-mismatch adult living donor liver transplantation using antigen-specific immunoadsorption and quadruple immunosuppression without splenectomy. Brown RS. Experience after the evaluation of potential donors for living donor liver transplantation in a single center. Evaluation of living liver donors with an all-inclusive 3D multi-detector row CT protocol.

Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg. Small-for-size graft in living donor liver transplantation: how far should we go? Split-liver transplantation: a review. A case report of split liver transplantation for two adult recipient in Korea. Safety and necessity of including the middle hepatic vein in the right lobe graft in adult-to-adult live donor liver transplantation. Reconstruction of the middle hepatic vein tributary in right lateral sector graft. Functional venous anatomy for right-lobe grafting and techniques to optimize outflow.

Congestion of right liver graft in living donor liver transplantation. Anterior segment congestion of a right liver lobe graft in living-donor liver transplantation and strategy to prevent congestion. Adult-to-adult living donor liver transplantation at the Asan Medical Center. Yonsei Med J. Liver Transplantation using a right lateral sector graft from a living donor to her granddaughter. Living donor liver transplantation with monosegment.

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Liver Transplant

Seventeen adult-to-adult living donor liver transplantations using dual grafts. Laparoscopic living donor hepatectomy for liver transplantation in children. Adult-to-adult living donor liver transplantation at the Asan Medical Center, Korea. Asian J Surg. Intermittent inflow occlusion in living liver donors: impact on safety and remnant function. Vein reconstruction modified right liver graft for living donor liver transplantation. Very few individuals require any blood transfusions during or after surgery.

All potential donors should know there is a 0. Other risks of donating a liver include bleeding, infection, painful incision, possibility of blood clots and a prolonged recovery. In children, living liver donor transplantations have become very accepted. Having a parent as a donor also has made it a lot easier for children - because both patients are in the same hospital and can help boost each other's morale. There are several advantages of living liver donor transplantation over cadaveric donor transplantation, including:. Living donor transplantation is a multidisciplinary approach.

All living liver donors undergo medical evaluation. Every hospital which performs transplants has dedicated nurses that provide specific information about the procedure and answer questions that families may have. During the evaluation process, confidentiality is assured on the potential donor.

Every effort is made to ensure that organ donation is not made by coercion from other family members. The transplant team provides both the donor and family thorough counseling and support which continues until full recovery is made.

The Facts About Liver Transplant: Survival Rates, Statistics, and More

All donors are assessed medically to ensure that they can undergo the surgery. Blood type of the donor and recipient must be compatible but not always identical. Other things assessed prior to surgery include the anatomy of the donor liver. However, even with mild variations in blood vessels and bile duct , surgeons today are able to perform transplantation without problems. The most important criterion for a living liver donor is to be in excellent health. Like most other allografts, a liver transplant will be rejected by the recipient unless immunosuppressive drugs are used.

The immunosuppressive regimens for all solid organ transplants are fairly similar, and a variety of agents are now available. Most liver transplant recipients receive corticosteroids plus a calcineurin inhibitor such as tacrolimus or ciclosporin , also spelled cyclosporine and cyclosporin plus a purine antagonist such as mycophenolate mofetil. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation.

Liver transplantation is unique in that the risk of chronic rejection also decreases over time, although the great majority of recipients need to take immunosuppressive medication for the rest of their lives. It is possible to be slowly taken off anti rejection medication but only in certain cases. It is theorized that the liver may play a yet-unknown role in the maturation of certain cells pertaining to the immune system [ citation needed ]. There is at least one study by Thomas E. Starzl 's team at the University of Pittsburgh which consisted of bone marrow biopsies taken from such patients which demonstrate genotypic chimerism in the bone marrow of liver transplant recipients.

The prognosis following liver transplant is variable, depending on overall health, technical success of the surgery, and the underlying disease process affecting the liver. These percentages are contributed to by many complications. Early graft failure is probably due to preexisting disease of the donated organ. Others include technical flaws during surgery such as revascularization that may lead to a nonfunctioning graft. As with many experimental models used in early surgical research, the first attempts at liver transplantation were performed on dogs.

The earliest published reports of canine liver transplantations were performed in by Vittorio Staudacher at Opedale Maggiore Policlinico in Milan, Italy. This initial attempt varied significantly from contemporary techniques; for example, Staudacher reported "arterialization" of the donor portal vein via the recipient hepatic artery, and use of cholecystostomy for biliary drainage.

The first attempted human liver transplant was performed in by Thomas Starzl , although the pediatric patient died intraoperatively due to uncontrolled bleeding. The introduction of ciclosporin by Sir Roy Calne , Professor of Surgery Cambridge, markedly improved patient outcomes, and the s saw recognition of liver transplantation as a standard clinical treatment for both adult and pediatric patients with appropriate indications.

The limited supply of liver allografts from non-living donors relative to the number of potential recipients spurred the development of living donor liver transplantation. There is increasing interest in improving methods for allograft preservation following organ harvesting. The standard "static cold storage" technique relies on decreased temperature to slow of anaerobic metabolic breakdown.

This is currently being investigated at cold hypothermic , body temperature normothermic , and under body temperature subnormothermic. Hypothermic machine perfusion has been used successfully at Columbia University and at the University of Zurich. The high incidence of liver transplants given to those with alcoholic cirrhosis has led to a recurring controversy regarding the eligibility of such patients for liver transplant.

The controversy stems from the view of alcoholism as a self-inflicted disease and the perception that those with alcohol-induced damage are depriving other patients who could be considered more deserving. The latter who gain control of alcohol use have a good prognosis following transplantation.

Once a diagnosis of alcoholism has been established, however, it is necessary to assess the likelihood of future sobriety.

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Historically, HIV was considered an "absolute" contraindication to liver transplantation. This was in part due to concern that the infection would be worsened by the immunosuppressive medication which is required after transplantation. Transplantation may be offered selectively, although consideration of overall health and life circumstances may still be limiting. From Wikipedia, the free encyclopedia. Liver transplantation Human liver. International Journal of Hepatology.

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Full Details Information. Retrieved Annals of Medicine and Surgery. Journal of Hepatology. Retrieved 29 March BBC News. Retrieved 3 August American Journal of Transplantation. NBC News. Nature Medicine. May Psychology Today. Graham, Jay A. Haddad, E. Cochrane Database of Systematic Reviews. O'Grady, J. Umeshita, K. Organ transplantation. Bone grafting Skin grafting Vascular grafting.

Non-heart-beating donation Organ harvesting Organ trade. Graft-versus-host disease Post-transplant lymphoproliferative disorder Transplant rejection. Organ transplantation in different countries Organ transplantation in China Organ transplantation in Israel Organ transplantation in Japan Gurgaon kidney scandal. Christiaan Barnard James D. Hartwell Harrison John P. Merrill Joseph Murray Michael Woodruff.